With Each Inhale, Another Wrinkle Will Cross Your Brow
While the concept could be a bit more dramatic, this commercial from DDB Toronto for Canada's Smoker's Helpline does an adequate job making the point cigarettes can take years off your life. With each puff of the cancer stick, another wrinkle may appear.
It's not as dramatic as, say, images of a man who's entire face is falling off (which we will spare you the sight of), but it does deliver the message.